Georgie: Admit he, he's adopted.Sheldon Cooper: How can I be adopted when I have a twin sister? Think, monkey, think.Missy Cooper: I wish I was adopted.Mary: That can still be arranged.
For your information, Sheldon does not look down on women. He looks down on everyone.
Tam: You know, sometimes you sound like a super villain.Sheldon: Silence!Tam: That'll be more effective after your voice changes.Sheldon: Silence!